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KMID : 0370220210650060405
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Yakhak Hoeji
2021 Volume.65 No. 6 p.405 ~ p.412
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Review on the Syntheses and Biological Activities of Oroxylin A and Its Derivatives
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Kim Ye-Eun
Lee Sang-Hyup
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Abstract
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Oroxylin A is a flavonoid compound found in some medicinal plants. Oroxylin A is known to possess a varietyof biological properties such as anti-cancer, anti-inflammatory, and neuroprotective effects. In particular, the anti-cancereffect via apoptosis induction and neuroprotective effect through γ-aminobutyric acid type A (GABAA) receptor antagonismare remarkable. Based on this usefulness, extensive efforts to synthesize oroxylin A have been continued. However, semisynthesesusing flavone compounds as starting materials rather than total syntheses were mainly conducted, owing to thedifficulty of synthesizing oroxylin A. Regarding the semi-synthesis of oroxylinA, several methods using flavonecompounds (baicalein, wogonin, or baicalin) were employed to give 8-62% product yields through 3-step reactions.
Derivative syntheses were also performed while investigating their biological properties. Therefore, syntheses and biologicalevaluation of oroxylin A and its derivatives were reviewed to assess and enhance the potential of oroxylin A as amedicinal component.
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KEYWORD
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Oroxylin A, Flavonoid, Anti-cancer, Anti-inflammatory, Neuroprotection
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